Early Remodelling of Perinuclear Ca Stores and Nucleoplasmic Ca Signalling During the Development of Hypertrophy and Heart Failure
نویسندگان
چکیده
Dept of Cardiology, Medical University of Graz, Graz, Austria; Ludwig Boltzmann Institute for Translational Heart Failure Research, Graz, Austria; Dept of Pharmacology, University of California, Davis, CA; Institute of Cell Biology, Histology and Embryology, Medical University of Graz, Graz, Austria; Institute of Experimental and Clinical Pharmacology, Medical University of Graz, Graz, Austria; Division of Transplantation Surgery, Medical University of Graz, Graz, Austria; Wales Heart Research Institute, Cardiff University School of Medicine, Cardiff, United Kingdom; Institute of Pharmacology and Clinical Pharmacy, Philipps-University of Marburg, Marburg, Germany *contributed equally
منابع مشابه
Early remodeling of perinuclear Ca2+ stores and nucleoplasmic Ca2+ signaling during the development of hypertrophy and heart failure.
BACKGROUND A hallmark of heart failure is impaired cytoplasmic Ca(2+) handling of cardiomyocytes. It remains unknown whether specific alterations in nuclear Ca(2+) handling via altered excitation-transcription coupling contribute to the development and progression of heart failure. METHODS AND RESULTS Using tissue and isolated cardiomyocytes from nonfailing and failing human hearts, as well a...
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